I'm a PFS sufferer that has been doing the HCG protocol for only a week now and seeing/feeling amazing benefits already. Several different methods are used in hair transplant surgery, including follicular unit extraction (FUE) and follicular unit transplantation (FUT). Post-finasteride syndrome is leaving behind a slew of victims in its trail. 8600 Rockville Pike If you stop with fin, then DHT should be back to normal in about 1-2 weeks (tissue binding lasts 4-5 days). Post-finasteride syndrome is a term thats used to refer to a range of symptoms associated with the use of finasteride as a treatment for hair loss and benign prostatic hyperplasia. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. The study also showed that the longer men are on finasteride, the more likely they are to develop PED. It can and does, although they typically arent common. Here we evaluate the scientific and clinical evidence in the contemporary medical literature to address the very fundamental question: Is PFS a real clinical condition caused by finasteride use or are the reported symptoms only incidentally associated with but not caused by finasteride use? If you come across such a doctor and are depending on him/her to treat your PFS, you would probably benefit from finding a doctor who is more knowledgeable about the condition. My physical and psychological strength is coming back. Ive made a 80% recovery so far and I keep improving however your hypothesis is quite scary. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Over time, it has been considered a safe and well Indeed, delineating the pathophysiological mechanisms underlying PFS will be of paramount importance to the understanding of this syndrome and to development of potential novel therapeutic modalities. Hi, no I dont have insomnia. Meanwhile, judging by the more than 3,000 PFS patients who have contacted the PFS Foundation since 2012, it appears that men in their late teens, 20s and 30s are most susceptible to the condition. We are in contact with many women around the world whove told us that, as a direct result of taking finasteride, they suffer from many of the same symptoms as male PFS patients. A few additional tests you can do include: Hey mate I have just stopped finasteride after 7 yrs on it. My blood level are ok only progesterone and colesterolo are higher than the max range. 2019 Jan 1;99(1):12-17. doi: 10.2340/00015555-3035. WebPost finasteride syndrome is a persistent adverse reaction to taking finasteride, a 5-alpha-reductase type II enzyme inhibitor that is extensively prescribed by doctors for hair loss or In fact, most evidence shows that side effects from finasteride become less common the longer the medication is taken. As a result of this, most medical bodies do not officially recognize post-finasteride syndrome as a medical condition. Always talk to your doctor about the risks and benefits of any treatment. CT really seems to help my symptoms, the colder the better! Finally, another way to treat male pattern baldness without using finasteride is via hair transplant surgery. The PFS Foundation is not a medical organization and, as such, cant offer health or medical advice. Finasteride, which is sold as a generic and under the brand name Propecia, is one of the most popular medications on the market for treating and preventing male pattern baldness. You are good person for sharing this. Lets say your DHT is low, here are the top 7 supplements you can use to increase it: If you want additional methods on increasing DHT apart from supplements, check out my comprehensive article on boosting DHT: If DHT is normal and you still feel off, mainly anxious, not confidence, shy, nervous, experiencing brain fog, etc., you might be low in allopregnanolone. 3 reasons why eating raw bull testicles for boosting testosterone is useless! The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. Disclaimer. I just picked up Gaba, im assuming this is a good idea? Q17: Can finasteride have an impact on male fertility? My goal is to get off Trazodone as quickly as possible, any recomendationsto further aid with insomnia ? PFS isnt fun. Sex Med Rev. Its pretty astounding the improvement in symptoms since the move. official website and that any information you provide is encrypted After finasteride is discontinued, the body must produce new 5-alpha-reductase molecules to replace the ones that were inactivated by the finasteride. For diagnostic criteria of the condition, see our PFS Diagnostic Criteria page.). One of the PFS Foundations chief goals is to achieve universal awareness and acceptance of PFS as a bona fide and serious medical condition. Most of the research used to support the idea of post-finasteride syndrome is low quality, with issues such as selection bias believed to affect results. Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. Noteworthy is that these two symptoms commonly coexist also in subjects who are not exposed to finasteride. For example, during the second, third and fourth years of the trial, 5.1 percent of men who used finasteride 5mg reported experiencing erectile dysfunction. >1000ng/dl Testosterone: My Step-by-Step Guide on How I Do It Naturally! The https:// ensures that you are connecting to the HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. However, we may soon see more data. Our Biotin Gummy Vitamins are formulated specifically for healthier hair, skin and nails. We require a human profile pic upon registration on this forum. cold penis I haven't tried Fens, but relate to the brainfog and depression and no morning wood or it getting spontaneously glorious. Sure I can do that for you. Therefore, we recommend caution and discussion with your physician about the potential risks before deciding to treat it with SSRIs. Reported symptoms include loss of libido, erectile dysfunction, depression, suicidal ideation, anxiety, panic attacks, Peyronies disease, penile shrinkage, chronic testicular pain, gynecomastia, muscle atrophy, cognitive impairment, insomnia and dry skin. I am 29 now and started at 22. Weve explained this process and its effects on your hair in our guide to DHT and male hair loss. Q7: Are there any cases of PFS patients whove gotten 100% better? This was a single center, prospective case-control study taking place between March 2013 and September 2018. I tried an illegal drug that increases dopamine and all of my issues went away briefly, so i think dopamine is a big piece of the puzzle here, especially with penis sensitivity. Hair transplant surgery provides permanent results, but it can be costly. I tried several different options before but Hims combined approach of all four methods by far created the best results., Hims has been the greatest confidence boost, no more bald jokes! We discourage the prescribing of finasteride for hair loss by any physician. Since testosterone is an important hormone for sexual desire and function, this could cause a reduction in libido. So thankful to have found this article. Practo Plus. Now, this doesnt mean that finasteride itself cant cause side effects. Some might be upregulated and some downregulated, so you might experience heightened serotonin responses. An adrenal gland problem that can cause anxiety disorders. I had no noticeable sides until sexual problems which started 3 weeks ago so I stopped. The men in the other group were not told that they would use finasteride and did not receive a briefing on potential side effects. Overall, men who take finasteride for at least 205 days are nearly five times more likely to develop PED than men who take it for less than 205 days. Careers. Epub 2020 Jun 26. I found some recovery stories with these compounds. Unfortunately, there have also been no published medical studies that report on the effectiveness of other antidepressants in the treatment of depression associated with PFS. The bottom line is that no one knows if tapering off is safer than abruptly discontinuing the drug. The first of these is the nocebo effect. According to the Post-Finasteride Syndrome Foundation, a 501(c)(3) nonprofit corporation thats dedicated to raising funds for research into post-finasteride syndrome, men with post-finasteride syndrome have reported the following physical symptoms: Sexual dysfunction, including a decreased sex drive or complete loss of libido, Loss of morning wood and spontaneous erections, Peyronie's disease (growth of scar tissue in the penis), Sexual anhedonia, or loss of pleasure from sexual stimulation and/or arousal, Ejaculation disorders, such as reduced ejaculatory volume and force, Gynecomastia, or male breast growth and sensitivity, Chronic fatigue and lack of energy and enthusiasm, Muscle pain, weakness, cramps, stiffness and twitching, Rhabdomyolysis (rapid breakdown of damaged or injured skeletal muscle), Dry, thinning skin and decreased production of sebum (an oily substance that products your skin), Melasma (a skin condition that involves patches of dark, discolored skin), Lipoatrophy (loss of fat tissue in specific areas of the body), Increased body mass index (BMI) and fat deposition, Reduced HDL cholesterol levels, raised triglycerides and fasting glucose, Increased rheumatoid factor (proteins produced by the immune system), Optic neuropathy (damage to the optic nerve inside the eyes), Ocular toxicity (drug-induced damage to the eyes). My test blood is perfect. This action is similar to the action of 5-alpha reductase inhibitors, such as dutasteride and finasteride. Glycine about 5g daily and niacinamide about 500mg-1g daily. Just wanna ask advice from a casual weed smoker as in vaping on weekends what would be a good supplement/nutritional addition to counter any negative effects? Topical finasteride works at the scalp level rather than systemically, and research suggests its effective at treating hair loss. Increasing carbon dioxide production. Important: FOR MEDIA ONLY. Huh? Finally, weve explained your options for treating and preventing hair loss if youre worried about developing post-finasteride syndrome. Federal government websites often end in .gov or .mil. PFS occurs in susceptible individuals even after small doses of the drug and can last for a long time after the discontinuation of treatment. In other words, the biological effects of finasteride ensure a relatively slow tapering of the drug effect over about 30 to 60 days, even if you stop the drug cold turkey. Epub 2022 Jul 14. Let me help you fine-tune your diet for maximal results. WebBased on patterns in firsthand experiences, the course may be understood in terms of three phases: post-withdrawal, adaptation and stabilization: This figure shows three outcomes: recovery, partial recovery and no recovery: Figure. There are some nice recovery stories on TR. Unable to load your collection due to an error, Unable to load your delegates due to an error. Before Unfortunately, a small minority of patients report increasing severity of symptoms over time, especially with respect to some of the psychological side effects. Would it be safer to just use Minoxidil (sporadically) or will I still potentially have symptoms? 200 mg of pregnenalone per day. Q5: Is there any cure, or at least treatment, for PFS? 2022 Oct;10(5):100543. doi: 10.1016/j.esxm.2022.100543. Also I jumped the gun on TRT out of frustration and desperation. Knowledge about PFS will also help to provide the best treatment for affected individuals and to properly educate patients before obtaining an informed consent for therapy with 5-steroid reductase inhibitors. The site is secure. Furthermore, we have reports from many patients who used topical finasteride solutions only and still developed PFS symptoms. Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. Have you tried getting loads of sunlight? Both are inconsistent. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. This article is for informational purposes only and does not constitute medical advice. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. To help with sleep I am also I use Magnesium , Lemon Balm, Taurine, Theanine and other sleep-aid herbs . WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type Im not beholden to trT. Post-finasteride syndrome is a controversial condition. Accessibility By the mid-1990s PEAs mechanism of action was discovered and linked to its ability to induce the brain biosynthesis of neuroactive steroid hormones, including allopregnanolone. A small subset of patients claims hormonal, psychological, and neurological symptoms that persisted despite stopping taking the medication. This site needs JavaScript to work properly. A: The PFS Foundation has a Patient Support program that does precisely that. Hi man, what have you done so far that helped you to 80% recovery? A third factor is that a lot of the problems commonly described as symptoms of post-finasteride syndrome are common in middle-aged and older men, particularly men in the age group that is most likely to develop noticeable male pattern baldness. Q11: Id like to get in touch with other PFS patients in my area, or anywhere in the world, for that matter. JavaScript is disabled. What kind of doctor would be willing to help with something like this? Premature ejaculation: the ultimate guide to fix it for good, Honey for erectile dysfunction: the sexual aphrodisiac food. 5 Apr 16, 2019 #1 Im very desperate for any success recovery story from finasterid side effects.. However, the 2017 PeerJ study (Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors finasteride or dutasteride) conclusively determined that the risk of developing PFS increases with increased duration of use. Q20: Im a PFS patient and Id like to do my part for PFS research by participating in a clinical study on the condition. In most, but not all, of these men, these sperm parameters will return to normal after quitting the drug. WebThis endocrine crash usually occurrs a few days or weeks after the cessation of treatment with 1 mg finasteride in these patients. Some men with PFS report symptoms that last for years after stopping finasteride. Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. At this point, you will not yet be registered on the forum. Additionally, although the drug is eliminated from the blood relatively quickly (half-life 4.8 to 6 hours), it remains active for much longer because it irreversibly binds to (and blocks the normal functioning of) the target enzyme 5-alpha-reductase (half-life 30 days). By blocking the conversion of testosterone to DHT, finasteride drastically reduces DHT levels in the body. PMC I took and i am taking many of the supplements listed with no real improvements. -DECREASED OR NO LIBIDO -DECREASED SEMEN VOLUME LOSS OF AM ERECTIONS The only problem is that I have an high PROGESTERONE and High colesterol out of higher range both. It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. As for hair loss shampoos, many include ingredients such as ketoconazole and saw palmetto to block DHT at the scalp level. CO2 keeps serotonin in check. I have had retraction of penis and man boobs. Finasteride binds to 5-R type 2 with high affinity and dissociates very slowly with a half-life of 31 days. Research has found that men who develop PFS generally dont show signs of reduced 5-alpha levels or androgen deficiency, but do show symptoms similar to those in people diagnosed with depression. Start Hair Visit, Medically reviewed by Katelyn Hagerty, FNP. Finasteride is known to deplete Allopregnanolone and this supplement should help you increase it which may provide relief to brain fog, depression, or insomnia. It was described that the prolonged use of 5-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. You do think that these hypothetical damages can be reversed ? This is to prevent the many spam account signups which we receive on a daily basis. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. There is evidence indicating that the longer someone takes finasteride, the higher the risk of developing PFS. Hi David, Its also worth noting that in practice, most hair transplantation surgery patients are treated with finasteride before and after the procedure. No one knows for sure. However, its still possible to take action and reduce the severity of your hair loss without using finasteride. Any other advice that would help is greatly appreciated. A: Yes. Diviccaro S, Giatti S, Cioffi L, Falvo E, Herian M, Caruso D, Melcangi RC. government site. To date, there are no evidence-based effective treatments for PFS. PFS, which is listed in the National Institutes of Healths Genetic and Rare Diseases Information Center, and in the database of the National Organization for Rare Disorders, describes persistent and serious side effects that continue long after the drug has been discontinued. WebRecovered from Post Finasteride Syndrome! Well, SSRI drugs almost never only inhibit the reuptake of serotonin, but they often also increase allopregnanolone, decrease serotonin receptor sensitivity, block certain serotonin receptors, release dopamine and histamine, etc. Are antidepressants safe for PFS patients? Sex Med Rev. Support inquiries will not be addressed. Answer: Hormonal optimization while on finesteride there are many options including peptides, and HCG as well as clomid/arimidex. In general, side effects from finasteride are rare, with only a small percentage of men affected at the typical finasteride dosage used to treat hair loss. Federal government websites often end in .gov or .mil. I will start Progesterone cream with tongkat ali soon. Also its strange. 2022 May 5. doi: 10.1038/s41443-022-00568-2. 2020 Sep;204(3):602. doi: 10.1097/JU.0000000000001168.01. This is a great video Ive shared many times over many HRT forums. MeSH This would suggest that tapering might be a safer approach. Muscle pain The brain fog has never gone away. So optimizing cellular function with CoQ10, necessary vits and minerals, thyroid hormones, neurosteroids, etc., should all be helpful at restoring the problem. Its also important to choose an experienced hair transplant surgeon to make sure you get satisfying, natural-looking results. (It is not known if PED in that subset ever subsided, or persisted.) I have another friend ready to start and I'm excited for his recovery next. With proper testing you know where to focus on. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. If a pill feels like an overwhelming way to treat male pattern hair loss, this spray with finasteride & minoxidil could be for you. really have been feeling like an empty husk like described lately, almost like a part of me was ripped out, but maybe one day i can find it again. It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. ). Thanks for helping people with this truly debilitating syndrome, in my case I was an othewise healthy active 66 year old that was prescribed Dudasteride for an enlarged prostate 3 months ago , after 7 weeks I stopped taking the drug and within several days I came down with a host of symptoms. Sexual functioning is returning to some extent. and transmitted securely. Feel free to discuss remedies, research, technologies, hair transplants, living with hair loss, cosmetic concealments, whether to "take the plunge" and shave your head, and how your treatment progress or shaved head or hairstyle looks. Very high levels of finasteride might then also be able to block 5R, which will reduce bile flow. Etc Etc After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. I have to recommend Hims to any guy whos experiencing thinning., Cost effective and affordable. Many websites that discuss post-finasteride syndrome describe it as a lifelong condition with no treatments or cures. In theory, the effects could be additive, but it is not known if the added effects would be beneficial or harmful. Please note that the PFS Foundation is not a medical organization and, as such, does not offer medical advice. The .gov means its official. It is important to note that many clinical studies suffer from incomplete or inadequate assessment of adverse events and often limited or inaccurate data reporting regarding harm. Bone pain ARE THE SEXUAL SIDE EFFECTS WORTH THICK HAIR? However, the PFS Foundation strongly discourages the use of finasteride for hair loss by anyone. Minoxidil doesnt block DHT. WebMain outcome measures: Neuroactive steroid levels in plasma and cerebrospinal fluid of postfinasteride patients and healthy controls. In these trials, researchers found that finasteride did cause several of the side effects mentioned above, including decreased libido, erectile dysfunction and ejaculation disorder. Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Other PFS patients anecdotally report PFS symptoms while using finasteride that get worse after quitting the drug. Learn more about our editorial standards here. Prostatis Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. And then you would possibly absorb better the UV. HCG increased my anxiety. I train a lot, heavy resistance, HIIT, play sport, drink very little. Like in the above trial, men placed in the control group received a non-therapeutic placebo. Anecdotally, many PFS patients report that their sexual symptoms gradually increase in severity over time while taking finasteride. If I do, could I develop PFS after stopping? (Needless to say, those professionals dont cover the entire world, which is why were always looking for more. Q12: I currently take finasteride but dont have any PFS symptoms. In the near future oral allopregnanolone analogs will be available to use in attempting to treat PFS patients. Finasteride; adverse events; alopecia; benign prostate hyperplasia; dutasteride; erectile disorder; libido; post-finasteride syndrome. 5-reduced steroids are significantly increased in a hyperthyroid state. Sexual dysfunction; depression; erectile dysfunction; loss of libido; suicidal ideation. 2019 Apr;7(2):277-282. doi: 10.1016/j.sxmr.2018.07.003. This is especially true once the placebo and nocebo effects are taken into consideration. According to the Post-Finasteride Syndrome Foundation, these may include: ). A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. It appears promising that treatment with PEA, by increasing allopregnanolone levels in PFS patients brains, could improve mood and reduce anxiety. The https:// ensures that you are connecting to the I am investigating other solutions. Its available as a liquid and as a foam and is applied directly to the areas of your scalp affected by male pattern baldness. It also improves blood flow to the scalp, which may help to supply your hair follicles with extra nutrients. DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. J Urol. I want to try HCG 50 UI per day. Brain fog JoeKool said: After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome. According to the Post-Finasteride Syndrome Foundation, these may include: Reduced memory and difficulty recalling information, Impaired ability to solve problems and comprehend information, General cognitive impairment and slowed thought processes, Depression, anxiety and/or suicidal ideation, Anhedonia (inability to feel pleasure) and emotional flatness, Insomnia (difficulty falling asleep or staying asleep). An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. Methods. Im a newbie here so dont hold me very accountable here. With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). Hello. I think he would suggest you "train" your skin to absorb more UV buy doing that yeah. WebFinasteride was the first on the market and is currently the most widely used inhibitor. 2022 Oct 26;12(11):1567. doi: 10.3390/biom12111567. Within the medical community, theres debate about whether post-finasteride syndrome is a real medical condition or something thats largely psychological. But the PFS Foundation is working as fast as possible to facilitate research that promises to identify the underlying biological mechanisms of PFS while laying the groundwork for the identification or development of effective therapies.
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